HPE ProLiant Gen12 Servers: Unleashing Intel Xeon 6 Performance and Direct Liquid Cooling

HPE unveils ProLiant Compute Gen12 servers sporting Intel Xeon 6 processors. The eight new servers deliver high performance and include robust security features.

Hewlett Packard Enterprise (HPE) introduced its ProLiant Compute Gen12 portfolio, featuring eight new servers boasting Intel Xeon 6 series processors. The new ProLiant series is designed to meet the demands of data-intensive workloads and hybrid cloud environments. These next-generation servers offer customers industry-leading performance, built-in security features, and the flexibility to scale as business and enterprise demands change.

The Gen12 servers integrate Intel Xeon 6 processors, delivering unmatched processing power to tackle complex workloads, including AI, edge computing, and data analytics. The new portfolio focuses on security and includes HPE iLO 7 with secure enclave technology, which provides chip-to-cloud protection against emerging threats and ensures compliance with the highest cryptographic standards.

The HPE ProLiant Compute Gen12 servers also feature AI-driven insights that improve operations management, automation, and energy efficiency. These servers with Intel Xeon 6 P-core processors are engineered to deliver up to 65% power savings annually, enabling organizations to achieve higher energy efficiency while reducing operational expenses. In addition, HPE is offering optional Direct Liquid Cooling (DLC) for selected models, helping organizations optimize their data center cooling and reduce their carbon footprint.

HPE ProLiant Compute Gen12 Servers Line-up

Hewlett Packard Enterprise will introduce six new ProLiant Compute Gen12 servers featuring the Intel Xeon 6 P-core processors in Q1 2025. The HPE ProLiant DL320, DL340, DL360, DL380, DL380a, and ML350 Gen12 offer customers scalable, cost-efficient, and agile solutions for various business needs.

Additionally, the HPE Synergy 480 blade server and the HPE ProLiant DL580 quad-processor Gen12 server are expected to be available this summer. Customers can purchase them via standalone or HPE GreenLake for flexibility and advanced management options.

Advancing Security For The Future

These servers feature a multi-layered security approach designed to safeguard every stage of the server lifecycle.

Key advancements include:

• HPE Trusted Supply Chain: Full visibility and control starting from the factory, ensuring the integrity of each ProLiant server.
• HPE Integrated Lights Out 7 (iLO): A trusted foundation for securing the server from manufacturing to end-of-life.
• Independent Security Processor: Offers tamper-resistant protection for keys, passwords, and configurations, elevating security standards.
• Quantum Computing Resistance: ProLiant Gen12 servers are equipped to handle future security challenges posed by quantum computing.
• FIPS 140-3 Level 3 Certification: HPE strives to meet this rigorous federal standard for security compliance.
• HPE Compute Ops Management: Enables proactive security management with centralized insights, customizable security baselines, and firmware vulnerability reduction.

HPE’s focus on delivering robust security capabilities in the ProLiant Gen12 servers ensures that customers are well-equipped to meet current and future security challenges.

HPE GreenLake and HPE Compute Ops Management

HPE continues to push the boundaries of compute management with its HPE Compute Ops Management (COM) platform, designed to simplify and enhance server lifecycle management. By integrating centralized control, automation, and AI-driven insights, COM empowers businesses to manage their compute infrastructure while maintaining security and compliance efficiently.

Key Benefits of HPE Compute Ops Management for Gen 12

• Enhanced visibility – Provides a single-pane-of-glass view for monitoring and managing servers across distributed environments, including edge, data center, and cloud.
• Lifecycle management – Streamlines firmware updates, security patching, and system maintenance, reducing operational complexity.
• AI-driven automation – Leverages predictive analytics and automation to optimize performance, reduce downtime, and enhance efficiency.
• Stronger security and compliance – Helps businesses maintain a secure and compliant compute environment with proactive risk assessments and remediation.
• Scalability and flexibility – Adapts to growing infrastructure needs, allowing businesses to manage thousands of servers effortlessly.
• API integrations – Seamlessly integrates with VMware vCenter, ServiceNow, Webhooks, and Redfish for improved automation and interoperability across IT ecosystems.

Recent Enhancements in HPE Compute Ops Management

• Faster time-to-resolve with improved map-based visibility.
• Improved operational efficiency powered by AI insights.
• Enhanced admin productivity with a faster UI response time in the new HPE iLO 7 UI redesign.

With strong customer adoption and positive feedback, HPE Compute Ops Management is a breakthrough in the industry. It allows businesses to achieve greater agility, reliability, and efficiency in their compute operations.

Direct Liquid Cooling

HPE continues to push the boundaries of energy-efficient data center solutions. To this end, it has introduced optional direct liquid cooling (DLC) for all its Intel-based HPE ProLiant Compute Gen12 one-socket and two-socket rack servers. As data center demands grow, more efficient cooling solutions become critical. Direct liquid cooling has proven pivotal, being over 3,000 times more effective at removing heat than traditional air cooling and providing enhanced thermal management.

Key highlights of HPE’s DLC innovation include:

• Industry Leadership: HPE has over 300 DLC patents and more than 50 years of experience in liquid cooling technology. The company is recognized for building the world’s fastest direct-liquid-cooled supercomputers.
• Fanless DLC Architecture: HPE delivers the industry’s first 100% fanless direct liquid cooling system, which reduces cooling power consumption by 90% compared to traditional air-cooled systems.
• Energy Efficiency: HPE’s 100% direct liquid-cooled systems power seven of the world’s top ten fastest supercomputers and eight of the world’s fifteen most energy-efficient supercomputers.
• Expansion to Gen12 Servers: HPE is bringing DLC to all Intel-based one-socket and two-socket Gen12 rack servers, extending its leadership in efficient, sustainable server cooling.

With this advanced cooling solution, HPE ensures optimal server performance and supports the global shift toward more sustainable, energy-efficient data centers. This DLC offering will be available for HPE ProLiant Compute Gen12 servers in Q1 2025, positioning HPE as a leader in the future of high-performance, energy-efficient computing.

The HPE ProLiant Compute Gen12 Line-up

DL320 Gen12

The HPE ProLiant Compute DL320 Gen12 is a 1U, single-socket server optimized for VDI, virtualization, containers, and hybrid cloud workloads. Designed for cost and power efficiency, it delivers significant upgrades over its Gen11 predecessor, with the Intel Xeon 6 processor and expanded storage configurations.

Key improvements include:

• Single Intel Xeon 6 support with up to 144 cores total
• Up to 2TB DDR5 memory (16 DIMM slots)
• Flexible storage options: up to 20x EDSFF, 8x SFF, or 4x/10x/12x LFF drive configs
• Up to 4 single-wide or 2 double-wide GPUs for enhanced acceleration
• PCIe Gen5 support with dual front or rear OCP slots
• Air and closed-loop liquid cooling and direct liquid cooling (DLC) options
• Integrated iLO 7 for management

With its high core density, storage versatility, and cooling enhancements, the DL320 Gen12 is a compact yet powerful solution for enterprises prioritizing scalability and efficiency in demanding environments.

DL340 Gen12

The HPE ProLiant Compute DL340 Gen12 is a 2U, single-socket server designed for cost and power efficiency while delivering high performance for hybrid cloud and data solutions. It supports Xeon 6 processors and a flexible GPU configuration, providing the scalability needed for modern workloads.

Key enhancements include:

• Single Intel Xeon 6 processor support with up to 144 cores total
• Up to 4TB DDR5 memory across (16 DIMM slots), ensuring high-speed performance
• Versatile storage options: up to 20x EDSFF, 8x SFF, or 12x LFF drives
• Powerful GPU support with up to 6 single-wide or 4 double-wide GPUs for accelerated workloads
• PCIe Gen5 expansion with up to six slots and dual front or rear OCP slots
• Optimized air cooling with standard or performance heatsink & fan kits for thermal efficiency and direct liquid cooling (DLC)
• Integrated iLO 7 for management

With its balance of compute performance, GPU acceleration, and cost efficiency, the HPE ProLiant DL340 Gen12 is an ideal choice for enterprises looking to scale hybrid cloud and data-driven applications without compromising energy efficiency.

DL360 Gen12

The HPE ProLiant Compute DL360 Gen12 is a 1U, dual-socket server engineered for high-performance computing across VDI, virtualization, containers, and hybrid cloud workloads. This rack-optimized solution builds on the strengths of its predecessor, delivering enhanced scalability and efficiency with Intel Xeon 6 processors and next-generation memory and storage capabilities.

Key enhancements include:

• Dual Intel Xeon 6 processor support with up to 144 cores per processor or 288 cores total
• Up to 8TB DDR5 memory across 32 DIMM slots, maximizing performance for intensive workloads
• Versatile storage options: up to 20x EDSFF, 10x SFF, or 4x LFF drives
• GPU support for up to 3 single-wide GPUs, accelerating AI and virtualization tasks
• PCIe Gen5 expansion with up to three slots and dual front or rear OCP options
• Advanced cooling solutions, including air, closed-loop liquid, and direct liquid cooling (DLC)
• Integrated iLO 7 for management

With its high-density design, cutting-edge architecture, and robust expandability, the HPE ProLiant DL360 Gen12 is a powerhouse server tailored for enterprises seeking optimal performance in space-constrained environments.

DL380 Gen12

The HPE ProLiant Compute DL380 Gen12 is a 2U, dual-socket server designed for flexibility and efficiency across VDI, virtualization, containers, and data management workloads. It is built to handle demanding applications and includes cutting-edge Intel Xeon 6 processors, high memory capacity, and scalable storage and GPU configurations to meet diverse enterprise needs.

Key enhancements include:

• Dual Intel Xeon 6 processor support with up to 144 cores per processor or 288 cores total
• Up to 8TB DDR5 memory across 32 DIMM slots, maximizing workload efficiency
• Scalable front storage options: up to 36x EDSFF, 24x SFF, or 12x LFF drives
• Powerful GPU support with up to 8 single-wide or 3 double-wide GPUs for acceleration
• PCIe Gen5 expansion with up to six slots and up to two front or rear OCP 3.0 slots
• Advanced cooling solutions, including air and direct liquid cooling (DLC)
• Integrated iLO 7 for management

With its high-performance architecture, extensive storage and expansion capabilities, and flexible cooling options, the HPE ProLiant DL380 Gen12 is a workload-optimized solution ideal for enterprises seeking scalability and efficiency in mission-critical environments.

DL380a Gen12

The HPE ProLiant Compute DL380a Gen12 is a 4U, dual-socket server designed for ultra-scalable GPU acceleration. It is perfect for fine-tuning and inferencing generative AI within large, complex workloads. Equipped with Intel Xeon 6 processors and comprehensive GPU support, this server is engineered to provide high-performance computing for demanding AI applications.

Key enhancements include:

• Dual Intel Xeon 6 processor support with up to 144 cores per processor or 288 cores total
• Up to 4TB DDR5 memory across 32 DIMM slots, providing ample capacity for large-scale workloads
• Flexible storage options: up to 16x EDSFF or 8x SFF drives
• High-performance GPU support with up to 16 single-wide or 8 double-wide GPUs, including support for NVIDIA H200 NVL, H100 NVL, L40S, and L4 GPUs
• PCIe Gen5 expansion with up to six slots and two OCP 3.0 slots
• Dedicated power supplies, with eight total power supplies and six dedicated to supporting GPUs
• Integrated iLO 7 for management

Designed for ultra-scalable GPU acceleration, the DL380a Gen12 is a powerhouse for AI-driven environments, providing the flexibility, speed, and computational resources needed to handle large language models.

ML350 Gen12

The HPE ProLiant Compute ML350 Gen12 is a dual-socket tower server for edge computing and SMB environments. Equipped with Intel Xeon 6 processors, it offers exceptional performance and scalability to support diverse workloads in compact, space-efficient deployments.

Key enhancements include:

• Dual Intel Xeon 6 Granite Rapids P-Core processor support with up to 86 cores per processor
• Up to 8TB DDR5 memory across 32 DIMM slots, ensuring optimal performance for memory-intensive tasks
• Wide range storage options:
  • Up to 12 LFF (Large Form Factor) HDD/SSD SAS/SATA
  • Up to 24 SFF (Small Form Factor) HDD/SSD SAS/SATA
  • Up to 16 SFF x4 NVMe SSDs
  • Up to 24 SFF x4 NVMe SSDs with x2 DA cable
  • Up to 12 EDSFF 3.S 1T
• GPU support for up to 8 single-wide or 4 double-wide GPUs, enabling advanced acceleration
• PCIe Gen5 expansion with up to 10 x8 slots and up to 2 x16 OCP 3.0 slots
• Air cooling solutions with standard or performance heatsink & fan kits and up to 8 fans for efficient thermal management
• Integrated iLO 7 for management

With its space-efficient tower design, powerful processing capabilities, and flexible expansion options, the HPE ProLiant ML350 Gen12 is a performance-optimized solution for edge and SMB applications. It offers scalability and cost-effective performance for growing businesses.

This latest HPE ProLiant Gen12 series portfolio provides customers with various options to meet various processing needs.

HPE ProLiant Compute Gen12 Servers

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