HPE has announced a significant expansion of the NVIDIA AI Computing by HPE portfolio, introducing integrated systems designed to scale enterprise AI deployments while maintaining security and governance. The update focuses on co-engineered, validated architectures intended to accelerate time-to-value for AI inferencing and model development.
HPE CEO Antonio Neri and NVIDIA CEO Jensen Huang positioned the collaboration as a new standard for enterprise AI infrastructure. The partnership centers on developing AI factories and grids that leverage HPE’s leadership in private cloud and networking to embed intelligence across enterprise workflows.
Scaling HPE Private Cloud AI and Security
HPE Private Cloud AI, a turnkey enterprise AI factory, now includes network expansion racks that allow deployments to scale up to 128 GPUs. This expansion provides a consistent operational experience for demanding AI workloads. For organizations requiring strict data isolation, a new air-gapped configuration is available to ensure sensitive data remains disconnected from external networks.
Security enhancements include the certification of HPE ProLiant Compute DL380a Gen12 servers for Fortanix Confidential AI. This solution uses NVIDIA Confidential Computing to process sensitive data on-premises without exposing it. Additionally, CrowdStrike is providing agentic security for the platform, offering AI-powered threat detection for infrastructure, models, and autonomous agents.
Software Blueprints and Blackwell GPU Support
The platform includes the latest NVIDIA AI Enterprise software and specialized blueprints. The NVIDIA AI-Q blueprint enables developers to build and control customizable AI agents, while the NVIDIA Omniverse blueprint supports digital-twin development. HPE is also updating its ProLiant servers and AI factories to support NVIDIA Nemotron open models, simplifying the deployment of production-ready agentic workflows.
Hardware updates include the availability of NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs across all HPE Private Cloud AI and AI factory configurations.
Specialized Solutions for Edge and Industry Use Cases
HPE introduced new multi-workload solutions co-designed with NVIDIA for retail, medical research, and manufacturing. These stacks combine HPE ProLiant servers with NVIDIA Spectrum-X Ethernet, BlueField DPUs, and ConnectX NICs. The architectures incorporate NVIDIA CUDA-X libraries, Multi-Instance GPU (MIG), and vGPU technologies, managed via HPE Compute Ops Management.
To support edge intelligence and small-language models, HPE is adding the NVIDIA RTX PRO 4500 Blackwell Server Edition GPU to the ProLiant portfolio. This includes integration with the NVIDIA Retail Shopping Assistant Blueprint to streamline sector-specific deployments.
High-Scale Networking and AI Data Pipelines
At NVIDIA GTC, HPE introduced networking solutions using HPE Juniper Networking routers and coherent optics to connect distributed AI deployments. The company also expanded its at-scale AI factories with systems built on the NVIDIA Vera Rubin architecture.
To address performance bottlenecks in AI data lifecycles, HPE is evolving the HPE Alletra MP X10000. The X10000 is the first object-based system to achieve NVIDIA-Certified Storage Foundation-level validation, confirming its ability to efficiently feed data to up to 128 GPUs for high-throughput training and low-latency inference. HPE also confirmed support for the NVIDIA STX rack-scale reference architecture for future storage solutions powered by Vera Rubin and BlueField-4.
Services and Financing
HPE Services launched an agents hub to help organizations adopt agentic AI with NVIDIA Nemotron models. Additionally, a new blueprint developed with Protopia AI enables trustworthy, multi-tenant AI factories for regulated environments. To assist with modernization costs, HPE Financial Services introduced the 90/9 Advantage program (no payments for 90 days, then 1% for the following 9 months) across the compute and networking portfolios.
Availability
- NVIDIA RTX PRO 4500 Blackwell Server Edition GPUs for HPE ProLiant: Q1 and Q2 2026.
- HPE Private Cloud AI (Air-gapped, RTX PRO 6000 support, AI-Q/Omniverse blueprints): Available now.
- Network expansion racks (up to 128 GPUs): July 2026.
- HPE and Protopia secure blueprint: Q2 2026.
- Fortanix support for HPE ProLiant DL380a Gen12: Q3 2026.
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